A simple synthesis of 2-thiohydantoins.
نویسندگان
چکیده
2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an alpha-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
منابع مشابه
A New synthesis of functionalized imidazo[2,1-b][1,3]thiazines with thiohydantoins, isocyanides and dialkyl acetylenedicarboxylates
The reaction of stoichiometric amounts of dialkyl acetylenedicarboxylates with alkyl isocyanides and 5,5-diaryl thiohydantoins in toluene and catalytic amount of p-TSA afforded imidazo[2,1-b][1,3]thiazines in good overall yields
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Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions
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ورودعنوان ژورنال:
- Molecules
دوره 11 10 شماره
صفحات -
تاریخ انتشار 2006